Shorter duration of preoperative symptoms is the most powerful predictor of favorable outcome after surgical treatment of SIH. ROC analysis yielded treatment within 12 weeks as a cut-off for better outcome. Neither sex, age, type of pathology, lumbar opening pressure, nor initial presentation were associated with the primary outcome. Symptom duration remained a significant predictor in a multivariate model ( p = 0.013). A significant association with the primary and secondary outcome was found only for preoperative symptom duration ( p = 0.001 and p < 0.001), whereby a shorter symptom duration was associated with a better outcome. Mean age was 46.7 years and 68.1% were female. Sixty-nine out of 86 patients (80.2%) returned the questionnaire and were analyzed. A cut-off value for continuous variables was calculated by a ROC analysis. Association between variables and outcome was assessed using univariate and multivariate regression. Secondary outcome was postoperative headache intensity on the numeric rating scale (NRS). Primary outcome was resolution of symptoms as rated by the patient. Subjects were surveyed by a questionnaire. We included consecutive patients with SIH treated surgically from January 2013 to May 2020. Aim of the study was to assess predictors for favorable outcome after surgical treatment of SIH. Yet, some patients suffer from residual symptoms. Microsurgery can sufficiently seal spinal CSF leaks. Spinal cerebrospinal fluid (CSF) leaks cause spontaneous intracranial hypotension (SIH).
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